Bone Health



Bone Health 

Bone is a living tissue, they are continuously being broken down and built back up in a process called remodelling (or bone turnover), for maintenance and for repair after injury and daily wear. New bone is made and old bone is lost throughout your life. However, as we age fewer minerals are deposited than are dissolved so bone density starts to decline. 

Our bones are complex structure and Provide protection to our all-body organ. 

The Bone is composed of mainly calcium, magnesium, and phosphorus attached to a structural matrix made of proteins collagen and glycoproteins and function as an endocrine organ (i.e., they produce hormones, osteocalcin). 

What Is the difference Between Osteopenia &Osteoporosis?

Osteopenia means poor or week bone, when BMD (bone mass density) is low we will suffer Osteopenia. If our osteopenia worsens to the point that your bones become brittle, it becomes an illness, called osteoporosis (literally, “porous bone”). Osteopenia is not a disease it’s only a condition which can happen in any age, but if we will not treat it, it may be cause to Osteoporosis.


Osteoporosis name comes from Latin for “porous bones.”it is a disease characterized by a decreased bone mass and an increased risk of fragility fractures. Osteoporosis is more common in women than in men, largely because of hormonal changes that occur during menopause.


What are the causes and Risk of Weak Bone?


Ageing: Ageing reduces bone strength because more bone is broken down than can be made – everyone develops osteoporosis if they live long enough.

Alcohol:  Excessive alcohol intake increases the risk of developing osteoporosis.

Breast cancer: Women with breast cancer have an increased risk of developing osteoporosis because of the treatments used and their effect on oestrogen levels.

Calcium: A lack of calcium affects bone strength and the muscles that support bones, so adequate intake is essential.

Corticosteroid therapy;

A steroid replacement hormone including:

•           Prednisolone

•           Cortisone

•           Hydrocortisone

•           Dexamethasone

Long-term use (more than 2 months) of oral corticosteroid type medications, with doses of more than 5-7.5mg of prednisolone per day, increases the risk of developing osteoporosis.

Eating disorders (including anorexia nervosa and bulimia): Eating disorders cause a loss of bone density because they create deficiencies in nutrition, which in turn affects hormone levels. If you develop an eating disorder after the process of skeletal growth has been completed you still risk reducing your bone mineral density.

Family history: You are at increased risk of osteoporosis if you have a family member with osteoporosis, especially a parent or sibling who has had a hip fracture.

Hormones: A drop in oestrogen can cause a loss in bone strength and this means bone density may be decreased:

•           if you have late onset of menstrual periods

•           absent or infrequent menstrual periods

•           by premature or early menopause

•           with menopause

Hyperthyroidism (overactive thyroid): High concentrations of thyroid hormone can lead to more bone breakdown than bone formation, which affects bone density and causes osteoporosis

Hypopituitarism (pituitary gland failure) Hypopituitarism can cause a deficiency in cortisol and the usual treatment is long-term replacement of the cortisol with corticosteroid drugs

There is increasing evidence the doses of corticosteroid drugs to replace the cortisol can lead to osteoporosis – usually this is when the dosage is too high or when there are other co-existing risk factors for osteoporosis

Physical inactivity: Lack of physical activity reduces bone and muscle strength, which increases the risk of fractures and falls.

Smoking: Smoking, especially how much you smoke, can cause: a significant reduction in bone density leading to an increased risk of fracture

Menopause: if you to experience menopause 1.5-2 years earlier, so you risk developing osteoporosis earlier than average.

Vitamin D: Low vitamin D can reduce the body's ability to absorb the calcium required for bone strength.

Vegans: Non vegan have lots of option for calcium from dairy products. 

Menopause: After Menopause women are at the higher risk of Osteoporosis.

What Food Are Healthy for Bone?

Dairy products: Dairy products such as low-fat and non-fat milk, yogurt and cheese Provides Calcium& Vitamin D.

Fish: Canned sardines and salmon (with bones)       Calcium., Fatty varieties such as salmon, mackerel, tuna and sardines Provides      Vitamin D

Fruits and vegetables: Collard greens, turnip greens, kale, okra, Chinese cabbage, dandelion greens, mustard greens and broccoli. Provides Calcium. 

Spinach, beet greens, okra, tomato products, artichokes, plantains, potatoes, sweet potatoes, collard greens and raisins Provides Magnesium

Tomato products, raisins, potatoes, spinach, sweet potatoes, papaya, oranges, orange juice, bananas, plantains and prunes Provides Potassium

Red peppers, green peppers, oranges, grapefruits, broccoli, strawberries, brussels sprouts, papaya and pineapple Provides Vitamin C

Dark green leafy vegetables such as kale, collard greens, spinach, mustard greens, turnip greens and brussel sprouts Provides Vitamin K

Fortified Foods

Calcium and vitamin D are sometimes added to certain brands of juices, breakfast foods, soy milk, rice milk, cereals, snacks and breads.           


Which Vitamins and Mineral are important For Bone?

Vitamin D: Vitamin D is fat soluble vitamins so automatically store in our body. But due to winter weather we can’t get enough sun light, Sun Light is the main source of Vitamin D.  It plays a key role in calcium absorption and helps regulate bone turnover.7

Vitamin K: Vitamin K ‘turns on’ a protein called osteocalcin which is necessary for bone building and bone healing. Some studies have shown that people with low intakes of vitamin K have lower bone density and a higher risk of fractures, although results have been varied and inconsistent. 12

{Vitamin K Activate Osteocalcin to bind with the calcium. Osteocalcin is the bone gla-protein (BGP), is the most abundant non-collagenous protein in bone matrix.6 Vitamin K is a multifunctional vitamin, which has gained the spotlight for its efficacy for enhancing bone turnover. Vitamin K promotes bone formation by stimulating the osteoblast differentiation, increasing the level of some bone formation markers (e.g., alkaline phosphatase and insulin-like growth factor), and regulating the extracellular matrix mineralization through Y-glutamyl carboxylation. Additionally, vitamin K prevents bone resorption via its anticatabolic activities, namely, decreasing osteoclast differentiation and inhibiting osteoblast apoptosis.8 }

Vitamin C: Vitamin C is the antioxidant, according to study it Supress the osteoclast activity. It acts as the Co-factor of collagen Formation. 3

Calcium: Calcium is a major component of bone tissue and essential for bone strength and structure. In fact, approximately 99% of your body’s calcium is stored in your skeleton. It gives strength to the bone and make it harder.  11

Magnesium: Magnesium is the fourth most abundant mineral in the body. It has been recognized as a cofactor for more than 300 enzymatic reactions, where it is crucial for adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Magnesium helps with calcium and vitamin D metabolism, mineralisation of bones, reducing bone loss, and helping nerves and muscles to work properly.12

Soy isoflavones: During menopause, estrogen levels in the body decline. This drop in estrogen can lead to bone being broken down faster than it can be formed, resulting in an increased risk of osteoporosis. 9,10

Other Nutrient Which Supports the Bones are 

  • Boron: Boron is a trace element that has been found to play a critical role in bone growth and maintenance.

  • Manganese: Manganese is distributed in tissues throughout the body, including bone; manganese activates phosphatases, kinases, decarboxylases. (38). Manganese plays as a co-factor in the formation of bone cartilage and bone collagen, as well as in bone mineralization

  • Selenium: Selenium is an essential nutrient and plays critical roles in a variety of physiological processes as constituent of selenoproteins which function as antioxidative scavengers and it has been reported that selenium inadequacy can influence bone metabolism. `

  • Zinc: Zinc stimulates cell differentiation, cell proliferation, and mineralization in osteoblasts through gene expression of various proteins including type I collagen, alkaline phosphatase, and osteocalcin,

SynBio Supporting Supplements for Bone

  • SynBio Bone+Muscle

  • SynBio Calcium + Vitamin D3

  • SynBio Vitamin D3+K2

  • SynBio D3 400IU, 800IU, 1000IU,3200IU

  • synBio Vegan Vitamin D3 800IU

  • SynBio Weekly D3 boost

  • SynBio Sport Complex (LGC Tested)

  • SynBio Sport Max (LGC Tested) 

  • SynBio Change Of life (Menopause formula)







References :


  2. A Ram Hong, and Sang Wan Kim, Effects of Resistance Exercise on Bone Health, Endocrinol Metab (Seoul). 2018 Dec; 33(4): 435–444.

  3. Shivani Sahni, PhD, Assistant Scientist II, Kelsey M Mangano, PhD RD, Post-Doctoral Fellow, Robert R McLean, DSc MPH, Assistant Scientist II, Marian T Hannan, DSc MPH, Senior Scientist, and Douglas P Kiel, MD MPH, Senior Scientist, Dietary approaches for bone health: lessons from the Framingham Osteoporosis Study, Curr Osteoporos Rep. 2015 Aug; 13(4): 245–255,doi: 10.1007/s11914-015-0272-1



  6. joanna Price, in Diagnosis and Management of Lameness in the Horse (Second Edition), 2011

  7. Li-Ru Chen,1,2 Peng-Hsuan Hou,1 and Kuo-Hu Chen, joanna Price, Nutritional Support and Physical Modalities for People with Osteoporosis: Current Opinion, Diagnosis and Management of Lameness in the Horse (Second Edition), 2011Nutrients. 2019 Dec; 11(12): 2848. Published online 2019 Nov 20. doi: 10.3390/nu11122848

  8. Solmaz Akbari 1 and Amir Alireza Rasouli-Ghahroud, Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies, Biomed Res Int. 2018; 2018: 4629383.

Published online 2018 Jun 27. doi: 10.1155/2018/4629383. 

  1. Meng-Xia Ji and Qi Yu, Primary osteoporosis in postmenopausal women, Chronic Dis Transl Med. 2015 Mar; 1(1): 9–13. Published online 2015 Mar 21. doi: 10.1016/j.cdtm.2015.02.006.

  2. Arun S. Karlamangla, PhD, MD, Sherri-Ann M. Burnett-Bowie, MD, MPH, and Carolyn J. Crandall, MD, MS, Bone Health during the Menopause Transition and Beyond, Obstet Gynecol Clin North Am. 2018 Dec; 45(4): 695–708. Published online 2018 Oct 25. doi: 10.1016/j.ogc.2018.07.012. 

  3. Giuseppe Della Pepa, and Maria Luisa Brandi, Microelements for bone boost: the last but not the least, Clin Cases Miner Bone Metab. 2016 Sep-Dec; 13(3): 181–185.

Published online 2017 Feb 10. doi: 10.11138/ccmbm/2016.13.3.181


  2. Giuseppe Della Pepa, and Maria Luisa Brandi, Microelements for bone boost: the last but not the least, Clin Cases Miner Bone Metab. 2016 Sep-Dec; 13(3): 181–185.Published online 2017 Feb 10. doi:10.11138/ccmbm/2016.13.3.181

Bone and Muscle

    Syn Bio Bone + Muscle

Bone is a living tissue; New bone is made and old bone is lost throughout your life. However, as we age fewer minerals are deposited than are dissolved so bone density starts to decline. We can stop this decline by providing Vitamins And minerals.

SynBio Bone + Muscles will provide Calcium, Vitamin D3, Vitamin K2 and Magnesium.

Our nutritional formula contains the vital nutrients essential to maintain healthy bones and connective tissue. These all ingredients are essential to maintain Bone Mass Density as Calcium give strength to the bone, Vitamin D3 absorb the Calcium to make bone strong, Vitamin K2 activate Osteocalcin to bind with calcium and help in Bone building process. Magnesium act as Co-factor For Vitamin D Binding and it also support the connective Tissue.

All these ingredients are carefully selected to provide you strong and healthy bone and Muscle.



SynBio Vitamin D3 400IU, 800IU, 1000IU, 3200IU and Liquid

Vitamin D not only plays a role in bone health; it also plays a different role in our body.

According to the new research study, Vitamin D Blocks Cancer, Protects Brain Cells, Lowers Diabetes Risk, Supports Cardiovascular Health. 

SynBio Calcium + D3

Vitamin D and Calcium Both are two Major Nutrients which support our Bone.

Calcium is a major component of bone tissue and essential for bone strength and structure. While Vitamin D Help in the Absorption OF Calcium.

SynBio Calcium + Vitamin D Vegan is specially formulated for Vegan Consumer.